Senior Associate Scientist Job Description
Senior Associate Scientist Duties & Responsibilities
To write an effective senior associate scientist job description, begin by listing detailed duties, responsibilities and expectations. We have included senior associate scientist job description templates that you can modify and use.
Sample responsibilities for this position include:
Senior Associate Scientist Qualifications
Qualifications for a job description may include education, certification, and experience.
Licensing or Certifications for Senior Associate Scientist
List any licenses or certifications required by the position: AALAS, ASCP, HTL, LATG, HT, DAWIA, ASR, LAT, SRA, DABT
Education for Senior Associate Scientist
Typically a job would require a certain level of education.
Employers hiring for the senior associate scientist job most commonly would prefer for their future employee to have a relevant degree such as Bachelor's and Master's Degree in Chemistry, Engineering, Biology, Biochemistry, Science, Computer Science, Statistics, Biotechnology, Molecular Biology, Chemical Engineering
Skills for Senior Associate Scientist
Desired skills for senior associate scientist include:
Desired experience for senior associate scientist includes:
Senior Associate Scientist Examples
Senior Associate Scientist Job Description
- Lead process development, scale-up, technology transfer and process validation activities
- Lead the implementation of Quality by Design (QbD) approaches for oligonucleotide development
- Lead outsourcing of Dynavax’s oligonucleotide API supply requirements, including vendor selection and contract negotiation as needed
- Author oligonucleotide CMC regulatory packages
- Execute, under supervisor’s direction, the development of in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
- Contribute to and help coordinate collaborative efforts, both internally and externally
- Generate, analyze, and report experimental results
- Participate in Immuno-oncology team meetings to present data and provide analysis
- Maintain familiarity with current techniques and procedures
- Assist with the evaluation of innovative technologies directly related to Immuno-oncology biomarker development
- Experience with gene therapy and/or vaccines would be preferredR&D
- PhD in chemistry or related scientific discipline with 5+ years’ relevant work experience, including 2 years’ in a leadership role in a CMC discipline such as process development, formulation
- Must have experience authoring CMC sections of Regulatory submissions
- Proven success in leading multidisciplinary project teams
- Expertise with oligonucleotide or small molecule drug development, scale-up and manufacturing for pre-clinical and clinical stages
- Must be a proven successful leader in building positive relationships across functional lines and able to influence positive decisions and build consensus
Senior Associate Scientist Job Description
- Identify process improvement opportunities and lead the implementation of these initiatives
- Monitor product performance to assess process capability and statistical control to ensure product validation status
- Identify trends and implement corrective actions as applicable
- Investigate and troubleshoot product deviations and production trends using technical and scientific skills
- Determine, along with team, corrective and preventive actions using the appropriate root cause analysis tools
- Work with other teams to address and solve technical issues
- Coordinate and monitor laboratory testing of experiment samples
- Develop and review validation protocols, coordinate resources, schedule qualification/validation runs and present results and conclusions
- Develop metrics and trending reports, initiate change controls, execute data analysis, participate in audits and manage projects of medium complexity
- Knowledgeable in protein science, cell culture and protein expression
- PhD -3+ years’ experience in open source programming languages for large scale data analysis
- Previous experience setting up cell based assays (proliferation, ELISAs, transfections, siRNA/shRNA knockdown) is required
- Execute and document work with great attention to detail
- Ability to prioritize tasks and fluidly transition between methods to perform tasks for multiple concurrent projects
- Working knowledge of GLP, CLIA and other applicable regulations/guidelines
- Must be productive within a team and as an individual contributor in a dynamic environment
Senior Associate Scientist Job Description
- Test samples from the process for cell viability, cell density, metabolites and titre and additional tests as required by the experimental plan
- Provide technical support for ongoing cell culture processes at laboratory and manufacturing scale
- Participate in maintaining scale-down models of the commercial or clinical process
- Effective execution of experiments and basic problem solving
- Ability to solve moderately complex issues independently
- Exercise significant technical discretion in the design and execution of a wide variety of experiments including quantitative data analysis and interpretation of results
- Use results to design new experiments
- Write complex protocols and technical reports
- Routinely identify new areas requiring evaluation
- Identify and troubleshoot complex manufacturing problems
- Must have established business acumen evidenced by successful achievements and contributions of new technologies, applications, and/or business opportunities
- This position may require travel up to 10%
- Extensive hands-on experience in direct binding studies using SPR is required
- Extensive experience and knowledge in majority of the following areas
- Execute formulation development activities such as performing hands on execution of experiments in laboratory prototyping, material characterization
- Experience in validation and qualification, troubleshooting, and technical writing is required
Senior Associate Scientist Job Description
- Make contributions to scientific publications and regulatory submissions
- Good knowledge of GMP manufacturing and process transfer
- Ability to resolve process development issues
- Ability to take a leadership role in groups and to influence others effectively
- Support all activities related to the MSAT lab in which harvest clarification, purification and analytical testing activities are performed
- Interface within MSAT team, Manufacturing, Quality, Validation, Quality Control, Lab Services and Facilities Services
- Ability to use computer effectively as work requires
- Apply a basic knowledge of biological manufacturing science in the design and execution of bioreactor experiments to identify and validate critical parameters that affect upstream bioprocess performance across multiple scales
- Working with senior level Scientists to systematically optimize the parameters that affect bioreactor performance through the application of statistical models for experimental design and analysis
- Subject matter expert in the CoE for assay development according to international guidelines
- Extensive hands-on experience with modeling software like S-PLUS/R, NONMEM, S-ADAPT, WinBUGS/OpenBUGS
- Experience supporting clinical development in the Oncology, Cardiovascular Disease, Immunology and/or Fibrosis is preferred
- Master’s degree or Ph.D in Computer Science, Applied Statistics, Engineering, Mathematics, Physics or other quantitative discipline with specialization and experience in Artificial Intelligence, Machine Learning, Natural Language Processing, Cognitive Science or other related areas
- A minimum of a M.S
- Experience in handling high-dimensional single cell data, mass cytometry, high-content imaging derived features is required
- Intermediate knowledge in chemistry, biology, biochemistry, and math, understanding of current Good Manufacturing Practices is required
Senior Associate Scientist Job Description
- You are able to apply skills and knowledge to all stages of chemical synthesis
- You support the management of intermediates testing, including technical review of draft protocols and study reports, help with program workflow
- You work reciprocally with internal groups
- Develop cell-based assays to be used in target validation studies
- Conduct cell-based assays based on various cell viability, apoptosis induction, and metabolomics readouts to enable a mid-stage drug discovery project
- Engineer cell lines (stable knockdown and/or overexpression) to test specific biological hypotheses
- Maintain good written records of laboratory procedures, results and conclusions
- Perform and report interim analysis of accumulated data to monitor work progress
- PhD with 0-2 years of post-doctoral experience
- Exceptional cell biology techniques (mammalian cell culture, transfections, and RNA interference)
- Experience in molecular biology, gene construct design and molecular cloning, reporter gene assays and engineering stable cell lines to support cell based assay development would be preferred
- Familiarity with analytical instrumentation and cGMP process equipment is desired
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- Specific Personnel Protective Equipment (PPE) is required when working in classified rooms
- Certain APIs, are considered high potent compounds
- BSc, MSc in microbiology, cell biology and physiology, chemical or biochemical engineering with 2-5 years’ experience in the industry for bioprocess development for manufacturing of high-value biological products