Scientist, Pharmacology Job Description
Scientist, Pharmacology Duties & Responsibilities
To write an effective scientist, pharmacology job description, begin by listing detailed duties, responsibilities and expectations. We have included scientist, pharmacology job description templates that you can modify and use.
Sample responsibilities for this position include:
Scientist, Pharmacology Qualifications
Qualifications for a job description may include education, certification, and experience.
Licensing or Certifications for Scientist, Pharmacology
List any licenses or certifications required by the position: AALAS, CLIA, FELASA, DABT
Education for Scientist, Pharmacology
Typically a job would require a certain level of education.
Employers hiring for the scientist, pharmacology job most commonly would prefer for their future employee to have a relevant degree such as Master's and Bachelor's Degree in Pharmacology, Biology, Pharmaceutical Sciences, Biochemistry, Biomedical Engineering, Biological Sciences, Cell Biology, Education, Molecular Biology, Chemistry
Skills for Scientist, Pharmacology
Desired skills for scientist, pharmacology include:
Desired experience for scientist, pharmacology includes:
Scientist, Pharmacology Examples
Scientist, Pharmacology Job Description
- Expand the Quantitative Pharmacology and modeling & simulation capability through evaluation and implementation of new data analysis techniques, software, computational infrastructure, personal technical skill, the strategic application of quantitative pharmacology and population based M&S methodologies across the development portfolio
- The Associate Principal Scientist is expected to work independently and collaborate as part of, or leading, a cross functional team
- Interact with regulatory regions
- Work closely with the CP-Therapeutic Area Lead to execute CP strategy for each project and deliver the required output
- Challenge yourself
- Coordinates contracting of GLP bioanalytical studies related to Array-sponsored toxicology and clinical studies, including deliverables, timelines, legal and financial aspects of contracts
- Develop and run cell based assays (50%)
- Mechanism of action studies to provide key data to projects (30%)
- Project team member (20%)
- Development of disease relevant cell-based model systems to understand the mechanism of action of therapeutic molecules
- PhD degree in a relevant scientific field
- Experience in progressing small molecules/and or biologics in immunology and/or immuno-oncology is highly desired
- Specific experience in using T reg, CD4/CD8, NK, macrophage/MDSC
- Hands on experience and detailed knowledge of in vitro cell based assay development for screening small molecules and/or biologics and associated technologies
- Demonstrated experience in drug discovery project through publications/posters
- Experience in oncology and in biotech or pharmaceutical industry are highly desirable
Scientist, Pharmacology Job Description
- Model, simulate and predict nonclinical and clinical data to drive decisions on dose and frequency of dosing
- Represent the Pharmacological Sciences Department on multi-disciplinary drug development teams and lead departmental sub-teams
- Interact with external collaborators, multi-company project teams regarding and outside contractors
- Write reports, sections to INDs, NDAs, and publish findings at the appropriate time
- Design and conduct in vivo pharmacology studies to evaluate MTD, PK/PD correlation and efficacy of novel therapeutic agents, investigate their mechanism of action in animal tumor models (syngeneic, cell line-derived and patient-derived xenograft model)
- Understand the concept of predictive biomarkers and contribute to model selection
- Analyze the results and present research findings to project teams
- Effectively collaborate with multi-disciplinary teams
- Manage out-sourcing projects when needed
- Keep up-to-date in the literature related to the projects
- BS in pharmacology or a related biological discipline
- Experience in one of the following areas of biology
- 7+ year relevant Industry experience in population PK, PK/PD modeling & simulation, and quantitative pharmacology in the pharmaceutical industry (Prospective applicants with <7 yrs experience need not apply)
- Highly skilled in state of the art and innovative methods of population PK and PK/PD modeling using NONMEM, R, MONOLIX
- Able to create and validate NONMEM or other Analysis Sets (ADS)
- Familiar with execution of Pop PK and PK/PD in a cluster or cloud environment
Scientist, Pharmacology Job Description
- Directly enable the conduct of in vivo studies, the ability to supervise/mentor other scientists/associates in the pharmacology group
- Participates in discovery teams to provide expertise and knowledge from the pharmacology discipline
- Develop research solutions that require extensive analyses and detailed investigation
- May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models
- May contribute to ex vivo analysis of tumor or immune cells by flow cytometry, IHC, ELISA, RT-PCR, or Luminex®
- Will manage multiple in vivo projects simultaneously, including working within a matrixed research environment to coordinate with project leaders and other functions
- Analyze data using appropriate statistical methods and present data in a professional format suitable for external publication
- Contribute to various projects outside of his/her own, collaborate with stakeholders from all relevant functions, and keep up-to-date in the literature related to his/her field
- Occasional weekend, evening, and holiday dosing/ animal monitoring required
- Contributes individually on cross functional teams
- Using a population based approach, develop PK and PK/PD models from clinical PK, efficacy and PD/biomarker data to support further dose selection, dosing regimens, and dose ranging throughout clinical development, leading to phase 3 dose selection and a proposed labeled dose
- Experienced in global submission of population PK analysis and analysis data sets
- Experienced in the handling of high frequency pharmacology data
- Experienced in drafting and finalizing population PK and PK/PD reports, regulatory summary documents, responses to global health authority inquiries, and other regulatory documents
- Experienced in a variety of quantitative approaches to drug development
- Hands on experience in population modeling and simulation
Scientist, Pharmacology Job Description
- Under general scientific and administrative direction, carries out independent research projects within function or across functional groups to develop and execute on research operating plans, new research and technology assessment proposals to advance in vitro pharmacology
- Supervise, train and mentor junior scientists to ensure continuous performance improvement and development and assist in aspects of recruitment and scientific supervision
- Proactively plan and execute own development strategy that applies technical and functional knowledge to design experiments/ projects that contribute to overall direction of function/discipline
- Ensure all activities comply with appropriate health and safety legislation, company codes of practice and local rules
- Provides expertise in biochemistry/biophysics or molecular/cellular pharmacology
- Under general scientific and administrative direction, this individual contributor position plans, direct and evaluates both self-initiated or assigned research programs within department/section or across departments to develop and execute on research operating plans and new research and technology assessment proposals to advance in vitro pharmacology
- Contribute to and implement the pharmacology department research strategy aligned with MSD Research Laboratories (MRL)’s drug discovery approaches and organizational objectives
- Supervise and train junior scientists in assay development and biochemical/cellular pharmacology methods for complicated and technically-demanding assays
- Operate with a high level of independence in assignments, capable of independently solving problems of low/medium complexity
- Promotes the use of novel experimental approaches within own area including implementation of advanced laboratory equipment, design of robust scientific experiments and routinely investigates/creates innovative processes, hypotheses and methodologies
- Possess strong scientific and technical expertise in the application of quantitative pharmacology and population PK modeling in drug development
- Able to utilize both classic and population analysis methods to best assess a concentration/exposure response relationship
- Proven record of independently identifying and solving tough problems repeatedly across a number of critical and diverse projects
- Demonstrated experience in processing, interpreting and communicating compound testing data
- Able to identify, justify and implement new cutting-edge technologies and approaches to fit drug discovery challenges
- Less than or equal to 3% travel, consisting of one relevant National scientific meeting and/or trip to Japan for project-related work per year
Scientist, Pharmacology Job Description
- Proactively plan and execute own development strategy that applies technical and functional knowledge to design experiments/ projects that contribute to overall direction of department/ discipline
- Develop and implement methodology to characterize target engagement of therapeutic molecules
- Design and develop innovative high throughput techniques for target-based and phenotypic screening
- Investigate molecular mechanisms of action of drug candidates and develop an understanding of receptor signaling and trafficking pathways involved
- Contribute to the scientific management of projects by participating in drug discovery teams in collaboration with Chemistry, Bioanalytical/ADME and In Vivo Pharmacology groups
- Create and advance concepts for new drug discovery projects
- Participate in the global scientific community through attendance at scientific conferences and publication of novel research findings in peer-reviewed, high quality journals
- Develop and execute in biochemical and biophysical assays, such as Caliper and Microscale Thermophoresis (MST), for lead discovery, hit optimization and lead optimization
- Able to analyze and interpret data and trouble-shoot with supervision
- Operates common laboratory equipment as needed
- May travel to scientific conferences and attend career development courses
- Cancer immunology background and/or experience with preclinical development of immuno-oncology therapeutics highly desired
- BS/MS with at least 5 yrs
- A broad knowledge and proven ability to evaluate, develop and troubleshoot in vivo models and systems for compound evaluation and a deep working knowledge of the animal models required to progress candidate molecules
- Connections with key opinion leaders in fields relevant to the disease area is helpful
- Experience/knowledge in gut physiology and the role of intestinal receptorI transporters or expertise in cardio-renal disease is a plus