Scientist, Pharmacology Job Description

Scientist, Pharmacology Job Description

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Scientist, pharmacology provides scientific and analytical support to measure drugs, antibodies, pharmacodynamics endpoints and biomarkers in biological matrices from preclinical projects.

Scientist, Pharmacology Duties & Responsibilities

To write an effective scientist, pharmacology job description, begin by listing detailed duties, responsibilities and expectations. We have included scientist, pharmacology job description templates that you can modify and use.

Sample responsibilities for this position include:

Manage Contract Research Organisations relationships and develop strategic partnerships as required
Remain current with clinical and drug development information and methods in modeling and simulation by engaging with the scientific community (e.g., publishing, presenting at meetings, participating in special interest groups within professional societies, ) and internalize key learnings back to Janssen
Apply appropriate regulatory (e.g., FDA, EMEA, ICH, ) guidelines in the design of clinical development plans and studies
Author study reports, sections to INDs, NDAs, and publish findings at the appropriate time
Hands on experience with isolation human primary cells and cell/tissues culture
Hands on experience with flow cytometry (FACS)and microplate based assays
Good understanding and working knowledge with isolation and manipulation of human blood cells
Hands on experience with in vitro T cell functional assays, such as, MLR, T cell activation, reporter assays
Experience with Cell cytotoxicity assays (Celltiter glo), ATPlite, Cell proliferation assays such as 3H-TdR incorporation, Cyquant
Stay upbreast with new technologies related to the field

Scientist, Pharmacology Qualifications

Qualifications for a job description may include education, certification, and experience.

Licensing or Certifications for Scientist, Pharmacology

List any licenses or certifications required by the position: AALAS, CLIA, FELASA, DABT

Education for Scientist, Pharmacology

Typically a job would require a certain level of education.

Employers hiring for the scientist, pharmacology job most commonly would prefer for their future employee to have a relevant degree such as Master's and Bachelor's Degree in Pharmacology, Biology, Pharmaceutical Sciences, Biochemistry, Biomedical Engineering, Biological Sciences, Cell Biology, Education, Molecular Biology, Chemistry

Skills for Scientist, Pharmacology

Desired skills for scientist, pharmacology include:

Antibodies
Relevant analytical methods
Excel
Immuno-oncology and cancer research
Immunology/inflammation
Incorporation of relevant biomarkers in preclinical proof of concept studies
Outsourcing CROs and monitoring of studies at outsourced sites
With an ability to follow novel scientific/technological developments for implementation in the lab
Word
Anti-infective drug targets and the context of pharmacologic intervention

Desired experience for scientist, pharmacology includes:

Decisive collaborative
Master’s degree in immunology/IONC or related field with at least 3-5 years of relevant laboratory experience in an academic or industrial setting
Bachelor’s degree in immunology/ IONC or related field with at least 5 years of relevant laboratory experience in an academic or industrial setting
Excellent presentation and intepersonal communication skills
Design execute and interpret cellular pharmacology experiments allowing Go/No Go decisions for immunology or immuno-oncology discovery projects
Impact project teams by being an active contributor (DT representative, DT lead) or project leader

Scientist, Pharmacology Examples

1

Scientist, Pharmacology Job Description

Job Description Example
Our company is growing rapidly and is hiring for a scientist, pharmacology. If you are looking for an exciting place to work, please take a look at the list of qualifications below.
Responsibilities for scientist, pharmacology
  • Expand the Quantitative Pharmacology and modeling & simulation capability through evaluation and implementation of new data analysis techniques, software, computational infrastructure, personal technical skill, the strategic application of quantitative pharmacology and population based M&S methodologies across the development portfolio
  • The Associate Principal Scientist is expected to work independently and collaborate as part of, or leading, a cross functional team
  • Interact with regulatory regions
  • Work closely with the CP-Therapeutic Area Lead to execute CP strategy for each project and deliver the required output
  • Challenge yourself
  • Coordinates contracting of GLP bioanalytical studies related to Array-sponsored toxicology and clinical studies, including deliverables, timelines, legal and financial aspects of contracts
  • Develop and run cell based assays (50%)
  • Mechanism of action studies to provide key data to projects (30%)
  • Project team member (20%)
  • Development of disease relevant cell-based model systems to understand the mechanism of action of therapeutic molecules
Qualifications for scientist, pharmacology
  • PhD degree in a relevant scientific field
  • Experience in progressing small molecules/and or biologics in immunology and/or immuno-oncology is highly desired
  • Specific experience in using T reg, CD4/CD8, NK, macrophage/MDSC
  • Hands on experience and detailed knowledge of in vitro cell based assay development for screening small molecules and/or biologics and associated technologies
  • Demonstrated experience in drug discovery project through publications/posters
  • Experience in oncology and in biotech or pharmaceutical industry are highly desirable
2

Scientist, Pharmacology Job Description

Job Description Example
Our company is growing rapidly and is hiring for a scientist, pharmacology. Please review the list of responsibilities and qualifications. While this is our ideal list, we will consider candidates that do not necessarily have all of the qualifications, but have sufficient experience and talent.
Responsibilities for scientist, pharmacology
  • Model, simulate and predict nonclinical and clinical data to drive decisions on dose and frequency of dosing
  • Represent the Pharmacological Sciences Department on multi-disciplinary drug development teams and lead departmental sub-teams
  • Interact with external collaborators, multi-company project teams regarding and outside contractors
  • Write reports, sections to INDs, NDAs, and publish findings at the appropriate time
  • Design and conduct in vivo pharmacology studies to evaluate MTD, PK/PD correlation and efficacy of novel therapeutic agents, investigate their mechanism of action in animal tumor models (syngeneic, cell line-derived and patient-derived xenograft model)
  • Understand the concept of predictive biomarkers and contribute to model selection
  • Analyze the results and present research findings to project teams
  • Effectively collaborate with multi-disciplinary teams
  • Manage out-sourcing projects when needed
  • Keep up-to-date in the literature related to the projects
Qualifications for scientist, pharmacology
  • BS in pharmacology or a related biological discipline
  • Experience in one of the following areas of biology
  • 7+ year relevant Industry experience in population PK, PK/PD modeling & simulation, and quantitative pharmacology in the pharmaceutical industry (Prospective applicants with <7 yrs experience need not apply)
  • Highly skilled in state of the art and innovative methods of population PK and PK/PD modeling using NONMEM, R, MONOLIX
  • Able to create and validate NONMEM or other Analysis Sets (ADS)
  • Familiar with execution of Pop PK and PK/PD in a cluster or cloud environment
3

Scientist, Pharmacology Job Description

Job Description Example
Our company is growing rapidly and is hiring for a scientist, pharmacology. If you are looking for an exciting place to work, please take a look at the list of qualifications below.
Responsibilities for scientist, pharmacology
  • Directly enable the conduct of in vivo studies, the ability to supervise/mentor other scientists/associates in the pharmacology group
  • Participates in discovery teams to provide expertise and knowledge from the pharmacology discipline
  • Develop research solutions that require extensive analyses and detailed investigation
  • May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models
  • May contribute to ex vivo analysis of tumor or immune cells by flow cytometry, IHC, ELISA, RT-PCR, or Luminex®
  • Will manage multiple in vivo projects simultaneously, including working within a matrixed research environment to coordinate with project leaders and other functions
  • Analyze data using appropriate statistical methods and present data in a professional format suitable for external publication
  • Contribute to various projects outside of his/her own, collaborate with stakeholders from all relevant functions, and keep up-to-date in the literature related to his/her field
  • Occasional weekend, evening, and holiday dosing/ animal monitoring required
  • Contributes individually on cross functional teams
Qualifications for scientist, pharmacology
  • Using a population based approach, develop PK and PK/PD models from clinical PK, efficacy and PD/biomarker data to support further dose selection, dosing regimens, and dose ranging throughout clinical development, leading to phase 3 dose selection and a proposed labeled dose
  • Experienced in global submission of population PK analysis and analysis data sets
  • Experienced in the handling of high frequency pharmacology data
  • Experienced in drafting and finalizing population PK and PK/PD reports, regulatory summary documents, responses to global health authority inquiries, and other regulatory documents
  • Experienced in a variety of quantitative approaches to drug development
  • Hands on experience in population modeling and simulation
4

Scientist, Pharmacology Job Description

Job Description Example
Our company is looking for a scientist, pharmacology. We appreciate you taking the time to review the list of qualifications and to apply for the position. If you don’t fill all of the qualifications, you may still be considered depending on your level of experience.
Responsibilities for scientist, pharmacology
  • Under general scientific and administrative direction, carries out independent research projects within function or across functional groups to develop and execute on research operating plans, new research and technology assessment proposals to advance in vitro pharmacology
  • Supervise, train and mentor junior scientists to ensure continuous performance improvement and development and assist in aspects of recruitment and scientific supervision
  • Proactively plan and execute own development strategy that applies technical and functional knowledge to design experiments/ projects that contribute to overall direction of function/discipline
  • Ensure all activities comply with appropriate health and safety legislation, company codes of practice and local rules
  • Provides expertise in biochemistry/biophysics or molecular/cellular pharmacology
  • Under general scientific and administrative direction, this individual contributor position plans, direct and evaluates both self-initiated or assigned research programs within department/section or across departments to develop and execute on research operating plans and new research and technology assessment proposals to advance in vitro pharmacology
  • Contribute to and implement the pharmacology department research strategy aligned with MSD Research Laboratories (MRL)’s drug discovery approaches and organizational objectives
  • Supervise and train junior scientists in assay development and biochemical/cellular pharmacology methods for complicated and technically-demanding assays
  • Operate with a high level of independence in assignments, capable of independently solving problems of low/medium complexity
  • Promotes the use of novel experimental approaches within own area including implementation of advanced laboratory equipment, design of robust scientific experiments and routinely investigates/creates innovative processes, hypotheses and methodologies
Qualifications for scientist, pharmacology
  • Possess strong scientific and technical expertise in the application of quantitative pharmacology and population PK modeling in drug development
  • Able to utilize both classic and population analysis methods to best assess a concentration/exposure response relationship
  • Proven record of independently identifying and solving tough problems repeatedly across a number of critical and diverse projects
  • Demonstrated experience in processing, interpreting and communicating compound testing data
  • Able to identify, justify and implement new cutting-edge technologies and approaches to fit drug discovery challenges
  • Less than or equal to 3% travel, consisting of one relevant National scientific meeting and/or trip to Japan for project-related work per year
5

Scientist, Pharmacology Job Description

Job Description Example
Our company is growing rapidly and is looking to fill the role of scientist, pharmacology. If you are looking for an exciting place to work, please take a look at the list of qualifications below.
Responsibilities for scientist, pharmacology
  • Proactively plan and execute own development strategy that applies technical and functional knowledge to design experiments/ projects that contribute to overall direction of department/ discipline
  • Develop and implement methodology to characterize target engagement of therapeutic molecules
  • Design and develop innovative high throughput techniques for target-based and phenotypic screening
  • Investigate molecular mechanisms of action of drug candidates and develop an understanding of receptor signaling and trafficking pathways involved
  • Contribute to the scientific management of projects by participating in drug discovery teams in collaboration with Chemistry, Bioanalytical/ADME and In Vivo Pharmacology groups
  • Create and advance concepts for new drug discovery projects
  • Participate in the global scientific community through attendance at scientific conferences and publication of novel research findings in peer-reviewed, high quality journals
  • Develop and execute in biochemical and biophysical assays, such as Caliper and Microscale Thermophoresis (MST), for lead discovery, hit optimization and lead optimization
  • Able to analyze and interpret data and trouble-shoot with supervision
  • Operates common laboratory equipment as needed
Qualifications for scientist, pharmacology
  • May travel to scientific conferences and attend career development courses
  • Cancer immunology background and/or experience with preclinical development of immuno-oncology therapeutics highly desired
  • BS/MS with at least 5 yrs
  • A broad knowledge and proven ability to evaluate, develop and troubleshoot in vivo models and systems for compound evaluation and a deep working knowledge of the animal models required to progress candidate molecules
  • Connections with key opinion leaders in fields relevant to the disease area is helpful
  • Experience/knowledge in gut physiology and the role of intestinal receptorI transporters or expertise in cardio-renal disease is a plus

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