Discovery Scientist Job Description
Discovery Scientist Duties & Responsibilities
To write an effective discovery scientist job description, begin by listing detailed duties, responsibilities and expectations. We have included discovery scientist job description templates that you can modify and use.
Sample responsibilities for this position include:
Discovery Scientist Qualifications
Qualifications for a job description may include education, certification, and experience.
Licensing or Certifications for Discovery Scientist
List any licenses or certifications required by the position: DABT, B/C, FELASA
Education for Discovery Scientist
Typically a job would require a certain level of education.
Employers hiring for the discovery scientist job most commonly would prefer for their future employee to have a relevant degree such as Master's and Bachelor's Degree in Biochemistry, Chemistry, Biology, Molecular Biology, Education, Cell Biology, Pharmacology, Biotechnology, Science, Industrial
Skills for Discovery Scientist
Desired skills for discovery scientist include:
Desired experience for discovery scientist includes:
Discovery Scientist Examples
Discovery Scientist Job Description
- An awareness of later stage development needs understanding of the disease state and biology will help to enable the definition of the required design elements
- Collaborate with discovery partners to evaluate molecular properties relevant to risk assessment from developability, drug-delivery and bioperformance perspectives, maintain close communication with the project team and influence team strategy
- Design and develop fit-for-purpose preclinical formulations (conventional and enabling) for pre-clinical toxicological and PK/PD studies to enable selection and progression of suitable drug candidates
- Perform fit-for-purpose analytical method development for small molecules and peptides, forced degradation analysis, preformulation studies, solubility measurement, and solid-state characterization using techniques such as, XRPD, DSC, TGA, vapor-sorption analysis
- Keep abreast with the scientific literature
- Keep current on rapidly evolving genomic technology platforms, especially DNA microarrays, RNA-Seq, DNA-Seq, and digital PCR
- Ability to perform proper tissue culture is a must
- Keep up-to-date on literature related to his/her field
- Initiate and maintain external collaborations
- Formulations (solution, suspension, emulsion, and solid dispersions) of small molecule chemical entities to support PK, pharmacology, and toxicology studies on a daily basis to enable IV and Oral PK studies in various animal species
- Hands-on experience to perform ELISA-based assays is required
- Assess existing strategies, improve and implement
- Set up lab, purchase equipment
- Work with Regulatory Affairs to set up appropriate taste evaluation protocols
- Drug discovery experience in a biotech or pharmaceutical environment is a plus
- Demonstrated their subject matter expertise in a number of areas
Discovery Scientist Job Description
- Cross-site and cross-functional communication to ensure alignment between the activities of the incumbent, the expectations of line management and the needs of the drug discovery team
- Develop IV/PO/SC formulations (solution, suspension, emulsion, and solid dispersions) of small molecule chemical entities to support PK and toxicity studies to discover novel solid forms (i.e., polymorphs, salts, co-crystals, and amorphous dispersions) of pre-clinical candidates
- Weigh in on decisions to progress various forms through preclinical development
- Generate and test hypotheses to pursue scientific goals in a timely manner
- Document experimental procedures in accordance with existing standard operating procedures and develop best practices
- Provide scientific leadership and creativity when developing strategies for gene discovery and optimization
- Combine computational biology/functional genomics information with genetic approaches to uncover causative variations and alleles of interest and to identify genome editing opportunities for agronomic traits of interest in maize and other crops
- Analyses of large data sets (genotypic, sequence and phenotypic data) and data mining from both in-house and public domain information to support projects
- Design and execute experiments to begin to understand the effect of causative variations on specific phenotypes in the context of commercial germplasm
- Manage experiments and data collection in a timely manner
- Master’s degree & at least 6 years of directly related experience, or
- Ph.D.’s degree with directly related experience
- Strong publication record reflecting experience and expertise in the study of human disease
- Master’s degree in Immunology, Cell Biology, Biochemistry, Pharmacology, or related discipline with at least 3 + years relevant lab research experience or Bachelor’s degree in Immunology, Cell Biology, Biochemistry, Pharmacology, or related discipline with 7 + years relevant lab research experience
- Core competencies required include solid knowledge in cell and molecular biology, immunology and in vitro pharmacology
- Experience with advanced cell culture approaches with cell lines, primary cells, and iPSC cells preferably with a focus on liver, cardiovascular, and immunotoxicity toxicity assays
Discovery Scientist Job Description
- Remain at the cutting-edge on technical and biological advancements by participating in professional meetings, career development activities and by encouraging others to bring information into research activities
- Ability to work effectively in cross-functional teams to complete experiments and meet goals in a timely manner
- Follow the safety and record keeping rules as per Pioneer’s policy
- On early target identification and validation in the therapeutic area of
- Assess and clearly communicate drug delivery and performance risks
- Maintain an awareness of and contribute to scientific literature
- Ability to independently prepare vehicles and formulations for use on study
- Independently perform routine sample processing procedures including sample acidification
- Independently prepare paperwork and materials in advance of study initiation
- Ability to use basic lab equipment such as pH meter, sonicator, and homogenizers
- Cell and molecular biology skills including development of reporter assays, application of knock-out, knock-down technology, gene expression analysis, and biomarker assay development and validation
- Skills in pathway analysis, network pharmacology
- 4 trips per year, mix of domestic and international
- Candidates must demonstrate a strong track record of scientific achievement and drug discovery knowledge
- Candidates should have a PhD with at least 5 years additional experience relevant to cancer drug discovery
- Strong organizational, interpersonal and communication skills (oral and writing) are a must
Discovery Scientist Job Description
- Ability to inventory, package and transfer/ship samples both internally and to clients
- Independently perform routine and non-routine procedures for sample preparation and analysis
- Ability to compile data and create data reports
- May provide technical direction and mentoring to less experienced staff
- Provide cross-functional support to other service lines as needed
- Identify and report difficulties with various aspects of extractions and analysis
- Ability to compile and create data reports
- Provide technical guidance and direction to the research staff
- Train to lead sponsor programs
- Follow company SOPs, policies and guidelines
- The ideal candidate will thrive in a dynamic and interactive multi-disciplinary team environment within the Oncology Discovery group at Takeda Boston
- Takeda’s high-engagement culture is an important factor in our success and we seek leaders who will contribute to and further strengthen that culture
- Previous leadership experience (supervising, coaching, mentoring, leading projects) is required
- A passion for delivering innovative new medicines for patients suffering with serious disease
- Experience in conducting preformulation studies, and forced degradation studies is required
- Experience in conducting analytical method development for small molecules and peptides, elucidating degradation mechanisms of drug candidates, measuring solubility and performing solid-state characterization is preferred
Discovery Scientist Job Description
- Ensure that raw data meets protocol, SOP and regulatory requirements
- Primary role is to design, execute, interpret and report in vitro experiments
- Develop disease relevant cell based models using primary neuronal/glial cells and cell lines
- Independently develop, execute, troubleshoot and validate new cell assays, protocols and cell imaging methods
- Characterize and validate functional antibody activity in cell based and in vivo models
- Collaborate with members from other functional areas, including medicinal chemistry, in vivo and in vitro pharmacology and translational sciences
- Communicate data clearly and concisely
- Interface with external academic, biotechnology, and contract research organizations
- Initiates, plans, conducts, and analyzes novel and routine primary immune and non-immune cell in vitro assays
- Able to effectively increase productivity through use of lab automation technologies and implementation of new assay formats
- Experience in applying novel formulation and drug delivery technologies to enable evaluation of drug candidates via oral and alternate routes in discovery and/or in development is preferredR&D
- Requires approximately 10% travel – expected to be infrequent
- Willingness to travel to various internal, collaborator and scientific meetings, including overnight trips
- Document experimental details and scientific findings, strong attention to detail
- Hands-on experience in CRISPR/Cas9 technology including optimization of experimental conditions, cutting efficiency and assay development using mechanistic and viability endpoints
- Experience in cancer genetics and cancer biology